Essential Oil Composition, Cytotoxicity against Hepatocellular Carcinoma, and Macro and Micro-Morphological Fingerprint of Laurus nobilis Cultivated in Egypt

GC/MS analysis of hydro-distillated essential oil (1.9% v/w) from fresh leaves Laurus nobilis cultivated in Egypt revealed the presence 81 components which 59 compounds were identified, identified represent 96.3 % composition. The major constituents 1,8-cineole (27.41%), linalool (19.37%), ?-terpinyl acetate (14.65%), methyl eugenol (7.73%), ?-terpineol, (2.84%), terpinen-4-ol (2.09%), elemicin (2.08%) and sabinene (1.80%). Qualitative quantitative identification was based on comparison retention indices (RIs) standard n-alkanes (C8-C24) mass spectra with those reported literature. exhibited potent cytotoxic activity against Hep-G2 (IC50= 1.83?g/mL). study enriched using molecular docking caspase3 (apoptotic enzyme). reflected ability 32 to interact at different sites initiating its activity. Moreover, macro- micromorphological studies plant’s leaves, petioles stem both entire isolated elements forms carried out. They characteristic cells fibers stems addition mucilage petioles, sclereids old small trichomes young surface.